Hamilton, ON (July 27, 2022) 카지노 게임 컬렉션� Researchers from McMaster 카지노게임사이트 and Queen카지노 게임 컬렉션�s 카지노게임사이트 have discovered a gut bacterial 카지노 게임 컬렉션�super-producer카지노 게임 컬렉션� of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS).

The culprit is what has now been named Klebsiella aerogenes, the McMaster-Queen's (MQ) strain, identified in up to 25 per cent of gut microbiota samples from patients with IBS. Researchers examined stool microbiota samples from both Canadian and American patient cohorts.

카지노 게임 컬렉션�We followed up these patients for several months and found high levels of stool histamine at the time when the patients reported severe pain, and low stool histamine when they were pain-free,카지노 게임 컬렉션� said senior author Premysl Bercik, professor of medicine of McMaster카지노 게임 컬렉션�s Michael G. DeGroote School of Medicine and a gastroenterologist.

The McMaster-Queen카지노 게임 컬렉션�s research team pinpointed the bacterium Klebsiella aerogenes as the key histamine producer by studying germ-free mice colonized with gut microbiota from patients with IBS. They also colonized some mice with gut microbiota from healthy volunteers as a control group.

The study found that the bacterium Klebsiella aerogenes converts dietary histidine, an essential amino acid present in animal and plant protein, into histamine, a known mediator of pain.

The bacterial histamine then activates the gut immune system through histamine-4 receptor, which draws immune mast cells into the intestines. These activated mast cells produce even more histamine and other pain-signalling mediators, triggering inflammation and pain.

카지노 게임 컬렉션�Now that we know how the histamine is produced in the gut, we can identify and develop therapies that target the histamine producing bacteria,카지노 게임 컬렉션� said first author Giada de Palma, assistant professor of medicine at McMaster.

The study found that when the mice colonized with histamine producing bacteria were fed a diet low in fermentable carbohydrates, bacterial histamine production dramatically decreased. This was due to change in bacterial fermentation and acidity within the gut, which inhibited the bacterial enzyme responsible for histamine production.

Bercik said that these results explain the beneficial effects of a low fermentable diet observed in patients with IBS.

It is known that patients with IBS have more mast cells in their intestines, and that some of them improve with treatments targeting mast cells or histamine, such as mast cell stabilizers or antihistamines.

카지노 게임 컬렉션�Although mast cell treatment in IBS has been explored, a novel approach based on our research would be targeting the bacterial histamine production or H4R pathways,카지노 게임 컬렉션� Bercik said.

The McMaster-Queen카지노 게임 컬렉션�s study explains why increased mast cells are found in IBS and suggests that H4 receptor pathway plays a major role in this process.

카지노 게임 컬렉션�If we block the H4 receptors, then we can prevent recruitment of mast cells to the colon and subsequently the development of abdominal pain,카지노 게임 컬렉션� said senior co-author Stephen Vanner, professor of medicine at Queen카지노 게임 컬렉션�s 카지노게임사이트.

카지노 게임 컬렉션�Many but not all IBS patients will benefit from therapies targeting this histamine driven pathway,카지노 게임 컬렉션� said co-first author David Reed, assistant professor of medicine at Queen카지노 게임 컬렉션�s. Reed said that one or more biomarkers of this pathway could be used to find the patients most likely to benefit.

The McMaster-Queens study was funded by the Canadian Institutes of Health Research.

The study was published in the journal Science Translational Medicine on July 27.

Editors:

Pictures of Premysl Bercik and Stephen J. Vanner may be found at

The paper is available at URL .

For information, please contact:

Veronica McGuire
Media Relations
Faculty of Health Sciences
McMaster 카지노게임사이트
289-776-6952
vmcguir@mcmaster.ca

Julie Brown
Manager, Media Relations
Queen's 카지노게임사이트
Brown.julie@muwangwooden.com
343-363-2763

Queen카지노 게임 컬렉션�s 카지노게임사이트:
Twitter: @Queensu; @QueensuMedia
Instagram: @queensuniversity
Facebook: @queensuniversity